Even though marijuana is listed as a dangerous drug, there have been no direct fatalities recorded. The overdose levels are far too high for anyone to ingest. In fact, the overdose levels are 1000 times higher than the effective dose of 15 mg. Any fatalities connected to marijuana have been due to driving while under the influence of THC, trouble with the law because of possession, or smoking weed during a pregnancy (infant fatality).
Donald Abrams was a member of the committee that reviewed the evidence that went into producing the report, and he said that the studies they reviewed overwhelmingly used pharmaceutically available preparations that contain THC, including dronabinol, nabilone and the whole-plant extract spray nabiximols, which contains equal parts CBD and THC. It’s impossible to know whether the benefits of cannabis can also be obtained from CBD alone, Abrams said, because CBD is just one of 400 chemicals present in the plant. So far, CBD in isolation has been studied in only a handful of randomized, placebo-controlled trials (considered the gold standard of evidence in medical research), and the evidence remains sparse.
In 2014, for the first time, the School of Medicine at the University of Nottingham conducted a study suggesting that cannabinoids affect blood vessels by causing them to relax and widen. By relaxing blood vessels, cannabis presents a natural way to lower blood pressure and improve circulation. Because this is the first human study evaluating the efficacy of cannabis in treating conditions of the heart, there is still more research to be done to prove that this is a safe method of treatment.
100% organic quality is all we deal. Only select, organic growers and extraction processes are used in any product found here. Our pure CBD oil products and tinctures get to work quickly through direct, oral administration. As a capsular, daily supplement, we also have some of the best in quality CBD supplements for the easy, daily maintenance option. For those that prefer vaping, we are also proud to feature an entire line of 100% organic CBD oil vaping products including dab oils, vape oils, and even high quality vape kits.
I'm reading this in disbelief. I feel kind of numb to be honest. I'm in collection for thousands because of all the medical treatments, surgeries, and travel. For nearly 8 years my wife has worked two and sometimes 3 jobs and every time I was well enough I worked two jobs trying to catch up and still we fell behind. Call it pride or stupidity, but we never asked for help of any kind. I take care of older neighbors and spend much of my free time working with disabled veterans. I feel like I've given everything I had to help others my whole life. Thank You one and all!
Our oils are not made from blends of different strains, and are in fact strain specific. Using the same strain each time means better consistency, so you can expect the same effects each time. Another advantage of using a single strain is that you can anticipate the effects of the oil based on its dried flower counterpart. If you’ve used a strain in dried flower format, you’ll receive similar effects with the oil, although the time course of effects is likely to be different.
CBD is a safe, long-term aid which is why it has gained such momentum and why our customers are turning to it for relief. CBD, scientifically known as cannabidiol, is a non-psychoactive, organic compound found in the hemp plant. When it interacts with the body’s endocannabinoid system, CBD provides powerful health benefits without the side effects of conventional drugs.
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In a study, 24 smoker subjects, who were randomly selected to receive either placebo or a Cannabidiol inhaler, were asked to take a puff from their inhaler each time they craved to smoke. The subjects were included on the basis of >10 cigarette consumption a day, who wished to quit this habit. They were devoid of any history of psychiatric illness or physical health issue. Observations revealed that those subjects who took cannabidiol inhaler experienced a 40 percent reduction in their cigarette consumption, whereas those who were on placebo underwent no change.
A sketchy outline of the cannabis genome already exists, but it’s highly fragmented, scattered into about 60,000 pieces. Kane’s ambitious goal, which will take many years to achieve, is to assemble those fragments in the right order. “The analogy I use is, we have 60,000 pages of what promises to be an excellent book, but they’re strewn all over the floor,” he says. “We have no idea yet how those pages fit together to make a good story.”
Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain. It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12. Although currently classified as orphan receptors, these receptors are most closely related phylogeneticaly to the cannabinoid receptors. In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist, and this action may be involved in its antidepressant, anxiolytic, and neuroprotective effects. It is an allosteric modulator of the μ- and δ-opioid receptors as well. The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.
After this devastating news, the family researched cannabinoids and found that they have been shown to inhibit the growth of tumor cells in culture and in animal models by modulating key cell-signaling pathways. Her family read that cannabinoids are usually well-tolerated and do not produce the generalized toxic effects of conventional chemotherapies. The family found promise in an organization that treated several cancers with cannabis oil.
I lean over to sniff one of the powdery, tightly clustered flower buds, purple-brown and coursing with white wisps. These tiny trichomes fairly ooze with cannabinoid-rich resin. This strain is called Highway Man, after a Willie Nelson song. Hybridized by Hague, it’s a variety loaded with THC. The best parts will be trimmed by hand, dried, cured, and packaged for sale at one of Mindful’s dispensaries. “This whole room will be ready for harvest in just a few days,” Hague notes with the subtle smirk of a competitive breeder who’s won international awards for his strains.
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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.
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