Seizures occur when there’s a dramatic fluctuation of electrical activity in the brain. Over the years, a number of high profile cases have raised awareness of CBD’s anti-seizure properties, but it’s only recently that science has been able to confirm this link. A randomized, double-blind, placebo-controlled trial published in The New England Journal of Medicine explored the effect of CBD medication on young adults with Dravet syndrome, a rare type of epilepsy with seizures that are often induced by fever. Those who received CBD experienced saw their seizure frequency drop by a median of 38.9 percent.
Look for what are known as “full-spectrum” CBD products. These products contain other compounds of the hemp plant in addition to CBD. It’s believed that the compounds work together to provide the claimed benefits, much as eating an orange is usually a better choice than drinking orange juice. One key exception is if you’re subject to workplace drug testing. A CBD isolate, in which the rest of the plant’s compounds are removed, should reduce the already tiny chance of trace amounts of THC being present.
The DEA isn’t the only government agency scrutinizing CBD vendors. To fend off the FDA, hemp oil companies contend their wares are not drugs but “dietary supplements.” Despite the suggestive “meds” in the company’s name, HempMedsPx is careful to note on its web site, “Although some of our founders are medical professionals, we cannot make medical claims about the benefits of our products.” Others are not quite so nuanced in their marketing. The internet is flooded with CBD products claiming to treat everything from seizures to arthritis to skin conditions and other maladies.
Watch Out For: Hemp grown in the European Union (EU) and China. Even in countries with agricultural regulations, the list of approved pesticides is far from safe. Thus you are really relying on the specific company’s ethical standards when it comes to hemp cultivation. The reason this is such a big deal with hemp when compared to other plants, is that hemp is a dynamic accumulator plant. Dynamic accumulator is a term used to describe plants that gather minerals – both good and bad – from the surrounding soil and store them in its tissues. So if you’re growing a hemp plant with petroleum-based pesticides in soil that contains heavy metals…you’re inevitably going to have a hemp plant containing both toxic pesticides and heavy metals. This is why many people have poor experiences when first trying CBD – you buy your vegetables organically, why not your hemp? The presence of these toxins is not regulated by any agency and they will end up in your CBD oil if you don’t purchase from the correct company. We like Ambary Gardens because they ensure that all of their CBD products are produced from organically and sustainably grown hemp without the use of pesticides.
We gave the highest points to companies that use a CBD distillate for their tinctures. The process of distillation creates an extract that is pure on a molecular level. There are people who think distillate is too pure, and that a full spectrum decarb produces a more effective tincture. But in light of the inconclusive evidence, we prefer a distillate. The process allows for a high degree of control as to the finished product. It’s also odorless and tasteless, so those tinctures tend to taste better.

While it’s surely a good thing to make CBD oil easily available for people all over the world, the increasing popularity of products rich in cannabinoids has a not so pleasant side effect. Driven by the desire to explore this business opportunity and get the most of it, producers use misleading marketing and deceptive advertising to increase profits.


Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[33] It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12.[14] Although currently classified as orphan receptors, these receptors are most closely related phylogeneticaly to the cannabinoid receptors.[14] In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist,[34] and this action may be involved in its antidepressant,[35][36] anxiolytic,[36][37] and neuroprotective effects.[38][39] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[40] The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.[8]
There’s also been a lot of talk lately about “microdosing” CBD. This refers to an incremental process of finding your minimum effective dose. You can do this with any concentration of CBD oil, but lower concentrations will take longer. In a 2017 article in Rolling Stone, Dr. Dustan Sulak outlines his protocol for microdosing. You can begin this process by asking yourself three questions:
...with due respect, your experience Locsta is almost precisely what happened with my....chihuahua. Degenerative disc disease, excruciating pain, prednisone worked, but couldn't keep her on it..pain killers and muscle relaxants didn't help, really thought I would have to put her down. Chi bloggers suggested CBD; gave PetReleaf a shot--like you, literally within minutes I could see the difference, in days she was pain free and now is back in charge of our world. The real key here is that with my dog, there is zero, nada, chance that there was any placebo effect...
How do you take it? CBD products comes in a variety of forms, including tinctures, gel caps, and topical applications. One athlete-focused company, Floyd’s of Leadville, offers a protein recovery powder and a carb drink that contain CBD. (That’s Floyd as in Floyd Landis, the former professional cyclist who was stripped of his 2006 Tour de France title for failing a drug test and who helped to expose Lance Armstrong’s doping.) Another athlete-focused company, PurePower Botanicals, offers capsules that combine CBD with herbs and other purported medicinals, such as turmeric. PurePower says that the non-hemp-derived ingredients increase the effectiveness of the products’ CBD.
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
In the United States, over three million people suffer from epilepsy – 470,000 of those people are children. Epilepsy is a disorder of the brain that causes seizures – of which there are over thirty different kinds, ranging from mild and infrequent to life-threatening. Not surprisingly, people with epilepsy face significant challenges – from the cost of healthcare to work limitations and social isolation.
Designed to provide the optimum absorption of CBD into the blood stream by employing a patented slow release delivery system. It’s well accepted that CBD is most effective when taken sublingualy, however most oils when taken in this way are swallowed and broken down by your body. The Gel-Tab™. is placed under the tongue and the CBD is slowly absorbed resulting in higher rates of CBD being absorbed than what would be achieved with a normal oil
In addition to positively affecting the endocannabinoid system, CBD has been the focus of more than 23,000 published studies about cannabinoids in relation to various medical indications including anxiety, epilepsy, inflammation, cancer and chronic pain to name few. For a more comprehensive look at these and other studies, visit our medical research and education page.
Stephanie, generally, I have patients take 20 to 150mg a day for sleep +/- anxiety. Start low and go slow. Know the dosages of your product. Usually 2/3 to 3/4 of the daily dose is 1-2 hours before bedtime, and the other portion is upon waking (to improve wakefulness during the day). Other factors such as stress, hormone replacement, other meds & medical conditions, etc. play a role along with individual differences. I own a compounding pharmacy, so we see a lot of unique needs. I can't give more specific advice in this forum, but there is help!
We also rated the product based on the type of CBD they used: isolate, full-spectrum decarb, broad-spectrum, or distillate. There’s a lot of debate around what is actually best, but our first decision was to give points to CBD oil that contains a range of cannabinoids. While there are certainly people with good reasons for choosing an isolate, there’s a lot of good evidence that CBD works better in combination with other cannabinoids (this is called the “entourage effect”).
For example, the six hemp oil companies the FDA had investigated in February had explicitly advertised CBD products for use in the “cure, mitigation, treatment, or prevention of diseases.” The agency sent warning letters to the companies, ordering them to change their product labeling or face potential legal action. Then, in May, the FDA announced it was excluding products containing cannabidiol from its definition of dietary supplements altogether. Hard, the spokesman for Medical Marijuana, Inc., said the company views “these developments as positive because this allows the debate regarding CBD to come to the forefront.” He characterized the FDA’s May announcement as “an opinion” and added, “Medical Marijuana, Inc. and HempMeds, along with industry associations, are working on determining how we can come to a mutual understanding on the matter with the FDA.”
100% organic quality is all we deal. Only select, organic growers and extraction processes are used in any product found here. Our pure CBD oil products and tinctures get to work quickly through direct, oral administration. As a capsular, daily supplement, we also have some of the best in quality CBD supplements for the easy, daily maintenance option. For those that prefer vaping, we are also proud to feature an entire line of 100% organic CBD oil vaping products including dab oils, vape oils, and even high quality vape kits.
Topical solutions also vary greatly in potency. For example, Prevail Botanical’s salve contains 1,000 milligrams of CBD in 2.2 ounces. Floyd’s of Leadville cream has 700 milligrams in a 30-gram (1.05 ounce) container. These deliver higher amounts of CBD than other topicals I tried, such as PlusCBD’s balm (100 milligrams in 1.3 ounces) and Medterra’s cream (750 milligrams in 3.4 ounces). Remember, more isn’t necessarily better.
While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
For patients suffering from seizures, the legalization of cannabis would be a decisive turning point. Epilepsy makes you desperate. Seizures are painful, sometimes debilitating. And then there are the aftershocks: broken teeth, bruises and cuts, lost time, humiliation. People with epilepsy are often depressed, and have more than double the suicide rate of the population at large. Epilepsy is also associated with a syndrome known as Sudden Unexpected Death in Epilepsy, wherein a previously healthy person with epilepsy simply dies without warning or explanation. Grinding on without relief isn’t an option, but getting help is enormously expensive. Research conducted by Charles Begley, a professor of public health at the University of Texas, found that epilepsy treatment costs between $8,500 and $11,000 per year. Real Scientific Hemp Oil is no less expensive than its pharmaceutical counterparts, with no assistance from insurance. A single three-gram vial costs $149, while a six-pack of 10-gram tubes can cost $1,999 (or $1,599 on sale). HempMedsPx suggests a “serving size” of 0.5 ml twice daily. Only when these drugs are recognized as such will insurance pick up the tab.
This is a hugely beneficial effect of CBD. Free radicals are the culprits when it comes to oxidative damage and inflammation. But CBD’s antioxidant properties can help to combat the negative effects of everyday exposure to elements that increase the production of free radicals. These elements include pervasive, but hugely unsurprising, things like:
Salve, scusate la domanda banale. La titolazione al 10% indica 1000 mg. Questo vuole indicare che in ogni goccia ci sono 1000 mg di CBD? Io soffro di dolore cronico, fibromialgia, colon irritabile. Voglio acquistare la titolazione alta ma non comprendo perfettamente il dosaggio. Sulla base della vostra tabella patologia/dosaggio ho letto di usare 20 mg per circa 25 giorni..ma non capisco a questo punto come regolarmi. Mi sapreste indicare voi in gocce come devo utilizzarlo? Grazie
Oral CBD products with a ratio of 20:1 or higher and administered as drops, capsules, or edibles can be very effective in treating pain, especially the inflammatory type. Most discussions of treating pain with CBD suggest that finding the right dosage is critical. Always start with the micro dose to test sensitivity and go up as needed within the dosing range by body weight until symptoms subside. The micro to standard dose is usually recommended to treat pain, but patients need to carefully monitor their condition and experiment to find the right formula; 10–40 mg of CBD or CBD+THC together is usually enough.

Heart disease is a growing problem today. In fact, it’s the leading cause of death in the U.S. A healthy diet and lifestyle is a top priority for heart health, but CBD oil can also help. According to research cannabidiol reduces artery blockage, reduces stress induced cardiovascular response, and can reduce blood pressure. It may also reduce cholesterol.
For example, the six hemp oil companies the FDA had investigated in February had explicitly advertised CBD products for use in the “cure, mitigation, treatment, or prevention of diseases.” The agency sent warning letters to the companies, ordering them to change their product labeling or face potential legal action. Then, in May, the FDA announced it was excluding products containing cannabidiol from its definition of dietary supplements altogether. Hard, the spokesman for Medical Marijuana, Inc., said the company views “these developments as positive because this allows the debate regarding CBD to come to the forefront.” He characterized the FDA’s May announcement as “an opinion” and added, “Medical Marijuana, Inc. and HempMeds, along with industry associations, are working on determining how we can come to a mutual understanding on the matter with the FDA.”
Cannabis has been used for centuries to treat nerves and anxiety, as well as other mood problems. CBD may help to improve both depression and anxiety, at least in part through its interactions with serotonin receptors in the brain. Research shows that CBD can reduce both mental and physical symptoms of anxiety. A study of CBD given to people before a public-speaking event indicates that CBD can help reduce stress—this and other research has shown that CBD can be an effective treatment for social anxiety.
Hemp also contains fatty acids which have been known to be great for the body. Unlike its marijuana counterpart, hemp contains high quantities of CBD and low volumes of THC for which its grown. While marijuana is illegal to consume in many states, hemp is slowly becoming more popular and more states are legalizing the uses of hemp oil for its citizens.
Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[33] It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12.[14] Although currently classified as orphan receptors, these receptors are most closely related phylogeneticaly to the cannabinoid receptors.[14] In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist,[34] and this action may be involved in its antidepressant,[35][36] anxiolytic,[36][37] and neuroprotective effects.[38][39] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[40] The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.[8]
The first step to finding your correct CBD dosage is getting as much information as you can about the product you’re using. What is the concentration of CBD? Are there third-party lab tests that can confirm that? The CBD industry is still mainly a grassroots therapeutic movement, and as such, largely unregulated. Concentration and purity levels can differ greatly depending on the manufacturing process.  
Over the past two years, 17 states have passed laws legalizing CBD so that patients can obtain the drug without fear of prosecution from local authorities. For intractable childhood epilepsies—the sorts of seizure disorders that for centuries have ruined lives and shattered families, the ones even specialists like Hernandez dread—CBD could be a miracle cure.

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Cannabinoids are neuroprotective, meaning that they help maintain and regulate brain health. The effects appear to be related to several actions they have on the brain, including the removal of damaged cells and the improved efficiency of mitochondria.[190] CBD and other antioxidant compounds in cannabis also work to reduce glutamate toxicity. Extra glutamate, which stimulates nerve cells in the brain to fire, causes cells to become over-stimulated, ultimately leading to cell damage or death. Thus, cannabinoids help protect brain cells from damage, keeping the organ healthy and functioning properly. CBD has also been shown to have an anti-inflammatory effect on the brain.[191]

CBD tinctures are some of the best all around CBD products! It’s hard to beat the convenience of having a few drops from a tincture as part of your morning routine, or taking the travel size with you on the go to use at your discretion. Looking for something more convenient and more effective? Check out our Full Line of CBD Capsules, Vape Pens and CBD Balms and Lotions
This is a common question and misconception. As mentioned above, while they come from the same plant, they are different strains and CBD is harvested from the plants that contain no THC (or negligible levels). CBD is completely legal and is not considered a drug. Because of the often confused history of these plants, many manufacturers use “hemp oil” instead of the more controversial “CBD oil” in their marketing. CBD levels can vary drastically based on manufacturing, so it is important to find a high quality manufacturer with verified levels.

This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.


CBD oil is similar to other products in that it is capable of being “watered down.” Some companies will try to eke out a higher profit margin by fooling their customers into thinking they’re getting more for less. It is important to pay attention to the concentration level of the CBD oil you’re buying in order to ensure you’re getting what you’re paying for. Although concentrations of CBD can vary quite a bit across the broad range of CBD products, a quality product will start off having somewhere between 250mg to 1,000mg per fluid ounce. This matters because if you were to purchase a 4 ounce bottle that contained 250mg of CBD, your concentration would be a mere 62.5 mg of CBD per ounce – hardly enough to reap the full benefits of CBD. It’s always important to look at the concentration level of the CBD you’re buying.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
These CBD-only laws also attempt to impose some regulation on CBD oils, such as establishing how much CBD and THC such products must contain. For example, on June 1, the day I sat down with Hernandez in Fort Worth, Texas, Governor Greg Abbott signed the state’s Compassionate Use Act into law in Austin. The law requires that all CBD products contain no more than 0.5 percent THC and at least 10 percent CBD. However, the bill does not specify how the state plans to enforce this requirement. The law contains no language outlining how laboratories can test CBD products, what kinds of standards they would use, or who would regulate them.

The words of these scientists convey the significance of the endocannabinoid system, first identified by Raphael Mechoulam in the mid-1990s and possibly one of the most important recent discoveries about the endogenous chemical transmitters involved in maintaining health. Endogenous (created naturally within the body) cannabinoids and their receptors are found not just in the brain but also in many organs as well as connective tissue, skin, glands, and immune cells. The list of CBD oil benefits and health concerns treatable by CBD is so long because these receptors are integral to so many bodily systems.


Neurologists are skilled at predicting side effects and interactions between well-researched pharmaceuticals. But due to the dearth of reliable research about CBD, doctors like Hernandez and Knupp cannot guide their patients in its use. If there are adverse reactions, Penny will find out because Harper will suffer through them. She has had to figure out through trial and error how best to mix and measure Harper’s oils. The bottom line, Penny said, is simple: “We are the research.”
Scientists have made a lot of progress in understanding how CBD produces its calming, pain-reducing, anti-inflammatory effects in the body—and there’s still more to learn. We know that CBD interacts with many different receptors, proteins, and other chemicals in the brain. These interactions create changes in the activity of neurotransmitters, hormones, and other cells throughout the brain and body. Through these interactions, CBD appears to be able to affect many of the body’s functions, from sleep-wake cycles and emotional regulation to inflammation, pain perception, and seizures.

We strive to carry only the best Hemp Extract and CBD Oil products for you and your loved ones. There are many brands and styles available throughout the marketplace. However, we purposely do not carry all brands that are made. We carry only the finest Extracts, Tinctures, CBD Vape Oil, and CBD Dabs-Wax products for our customers. We want to make sure that if you come to buy cannabinoid products from us, you can rest assured that what you’re getting is truly the best of the best.

Cannabis Oil: Cannabis oil is typically made from marijuana with a high THC percentage. Therefore, it must be purchased in an area where marijuana is legal or can be obtained with a prescription. The amounts of compounds, including CBD and THC, will drastically vary from product to product. Commercially produced cannabis oils will have more controlled concentrations of CBD and THC for medical purposes.


I have also called a couple places to get some input about what we may need, but they all said they cannot give advice. Then HOW do we know what to get. As for MOST of us, we are by no means well off. Quite the opposite, in fact. So to keep “trying” a bunch of different ones is not an option. Blue Bird in CO give discounts to low income, so would like to use their products if possible.

As I mentioned earlier, when consumed, the cannabinoids found in CBD attach themselves to certain receptors in your brain and immune system. One such receptor, the CB2 receptor, helps manage pain and inflammation in your immune system. When you use CBD oil for pain, it impacts the way your brain and body respond to the signals they’re sent—ultimately helping to reduce pain and inflammation.

Today, dozens of companies produce CBD in an array of forms. CBD can be inhaled through vape pens, applied in topical salves, ingested in edibles, or swallowed in oil-based tinctures. Oil has become the dominant CBD delivery method for kids with epilepsy, since it is easy to administer and ingest, and there is no shortage of it available for sale online. There are dozens of companies boasting names like Healthy Hemp Oil, Dose of Nature, and Natural Organic Solutions, each of them selling CBD products at prices ranging from trivial to dizzyingly steep. You don’t have to look hard to find them. If you have a PayPal account and $100 to spare, you could have a vial of hemp oil delivered to your doorstep.


But there’s a big difference between the two. Hemp seed oil has been pressed from hemp seed, and it’s great for a lot of things – it’s good for you, tastes great, and can be used in soap, paint – even as biodiesel fuel. However, hemp seed oil does not contain any concentration of cannabinoids at all, including CBD. So by all means, stock up at your local natural food store. Just don’t expect to reap the benefits of a true CBD oil when you cook with hemp seed oil.
When extracting THC from the cannabis plant, it’s not easy to separate the THC from the mixture. This requires skill, expertise, and technology. Some shady brands create DIY CBD oils by using dangerous solvents, and then try to sell their products online. They sell them at extremely low prices, looking to make a quick buck. Before purchasing, always make sure that the CBD oil you are looking at has no psychoactive effects, and makes sure that it has been extracted with CO2 techniques as this ensures that no dangerous chemical solvents were used. And remember that THC is illegal in most states, so you don’t want to get on the wrong side of the law.

CBD Oil Benefits

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